
Probiotics/synbiotics used in clinical trials of patients undergoing abdominal surgery
Author | Year | Patient number | Indication for surgery | Duration of treatment (day) | Included strains (substrates in synbiotics) |
---|---|---|---|---|---|
Synbiotics | |||||
Rayes et al. [31] | 2002 | 90 | Major surgery | 5 |
|
Kanazawa et al. [16] | 2005 | 55 | Biliary cancer | 14 |
|
Sugawara et al. [17] | 2006 | 101 | Liver/biliary surgery | 28 |
|
Rayes et al. [27] | 2007 | 89 | Pancreatic surgery | 9 |
|
Horvat et al. [24] | 2010 | 76 | Colorectal surgery | 3 |
Mixture of 4 |
Eguchi et al. [36] | 2011 | 50 | Liver transplantation | ||
Usami et al. [12] | 2011 | 67 | Liver resection | 26 |
Yakult BL seichoyaku (galacto-oligosaccharides) |
Tanaka et al. [13] | 2012 | 64 | Esophagectomy | 22 |
|
Okazaki et al. [14] | 2013 | 53 | Upper GI, hepatobiliary, pancreatic cancer | 17 |
|
Sommacal et al. [32] | 2015 | 54 | Periampullary tumor | 14 |
|
Komatsu et al. [33] | 2016 | 379 | Colorectal surgery (laparoscopic) | 9~18 |
|
Yokoyama et al. [28] | 2017 | 50 | Pancreatico-duodenectomy | 21 |
|
Flesch et al. [35] | 2017 | Colorectal cancer | 19 |
||
Polakowski et al. [34] | 2019 | 77 | Colorectal cancer | 7 |
|
Park et al. [40] | 2020 | 68 | Colorectal cancer | 28 |
|
Probiotics | |||||
McNaught et al. [25] | 2002 | 129 | Major surgery | 14 |
|
Nomura et al. [37] | 2007 | 70 | Pancreatic surgery | Variable |
|
Liu et al. [18] | 2011 | 120 | Colorectal surgery | 16 |
|
Zhang et al. [15] | 2012 | 60 | Colorectal cancer | 3 |
|
Liu et al. [26] | 2013 | 161 | Colorectal cancer | 16 |
|
Sadahiro et al. [29] | 2014 | 310 | Colorectal cancer | 7~23 |
|
Kotzampassi et al. [38] | 2015 | 164 | Colorectal cancer | 14 |
|
Yang et al. [30] | 2016 | 92 | Colorectal cancer | 12 |
|
Grąt et al. [39] | 2017 | 55 | Liver transplantation | Variable |
GI = gastrointestinal.
aPostop only; b(/)Pre & postop (duration of preoperative treatment/postoperative treatment).