Annals of Clinical Nutrition and Metabolism : eISSN 2799-8363 / pISSN 2799-7898

Table. 1.

Table. 1.

Probiotics/synbiotics used in clinical trials of patients undergoing abdominal surgery

Author Year Patient number Indication for surgery Duration of treatment (day) Included strains (substrates in synbiotics)
Synbiotics
Rayes et al. [31] 2002 90 Major surgery 5a Lactobacillus plantarum 299v (oat fiber)
Kanazawa et al. [16] 2005 55 Biliary cancer 14a Bifidobacterium breve, Lactobacillus casei (galacto-oligosaccharides)
Sugawara et al. [17] 2006 101 Liver/biliary surgery 28b (14/14) Lactobacillus casei Shirota, Bifidobacterium breve strain Yakult (galacto-oligosaccharides)
Rayes et al. [27] 2007 89 Pancreatic surgery 9b (1/8) Pediococcus pentosaceus, Leuconostoc mesenteroides, Lactobacillus plantarum, Lactobacillus paracasei (beta glucan, inulin, pectin, resistant starch)
Horvat et al. [24] 2010 76 Colorectal surgery 3a Mixture of 4 Lactobacilli (beta-glucan, inulin, starch, pectin)
Eguchi et al. [36] 2011 50 Liver transplantation Bifidobacterium breve, Lactobacillus casei (galacto-oligosaccharides)
Usami et al. [12] 2011 67 Liver resection 26b (14/12) Yakult BL seichoyaku (galacto-oligosaccharides)
Tanaka et al. [13] 2012 64 Esophagectomy 22b (1/21) Lactobacillus casei Shirota, Bifidobacterium breve strain Yakult (galacto-oligosaccharides)
Okazaki et al. [14] 2013 53 Upper GI, hepatobiliary, pancreatic cancer 17b (7/10) Lactobacillus casei Shirota, Bifidobacterium breve Yakult (galacto-oligosaccharides)
Sommacal et al. [32] 2015 54 Periampullary tumor 14b (4/10) Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus casei, Bifidobacterium bifidum (fructo-oligosaccharides)
Komatsu et al. [33] 2016 379 Colorectal surgery (laparoscopic) 9~18b (7~11/2~7) Lactobacillus casei Strain Shirota, Bifidobacterium breve strain Yakult (galacto-oligosaccharides)
Yokoyama et al. [28] 2017 50 Pancreatico-duodenectomy 21b (7/14) Lactobacillus casei Strain Shirota, Bifidobacterium breve strain Yakult (galacto-oligosaccharides)
Flesch et al. [35] 2017 Colorectal cancer 19b (5/14) Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus paracasei, Bifidobacterium lactis (fructo-oligosaccharides)
Polakowski et al. [34] 2019 77 Colorectal cancer 7a Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus casei, Bifidobacterium lactis (fructo-oligosaccharide)
Park et al. [40] 2020 68 Colorectal cancer 28b (7/21) Bifidobacterium animalis subsp. lactis HY8002, Lactobacillus casei HY2782, Lactobacillus plantarum HY7712 (lactose, xylitol, maltitol)
Probiotics
McNaught et al. [25] 2002 129 Major surgery 14b (9/5) Lactobacillus plantarum 299v
Nomura et al. [37] 2007 70 Pancreatic surgery Variableb Enterococcus faecalis, Clostridium butyricum, Bacillus mesentericus
Liu et al. [18] 2011 120 Colorectal surgery 16b (6/10) Lactobacillus plantarum, Lactobacillus acidophilus, Bifidobacterium longum
Zhang et al. [15] 2012 60 Colorectal cancer 3a Bifidobacterium longum, Lactobacillus acidophilus, Enterococcus faecalis
Liu et al. [26] 2013 161 Colorectal cancer 16b (6/10) Lactobacillus plantarum, Lactobacillus acidophilus, Bifidobacterium longum
Sadahiro et al. [29] 2014 310 Colorectal cancer 7~23b (2~8/5~15) Bifidobacteria
Kotzampassi et al. [38] 2015 164 Colorectal cancer 14a Lactobacillus acidophilus, Lactobacillus plantarum, Bifidobacterium lactis, Saccharomyces boulardii
Yang et al. [30] 2016 92 Colorectal cancer 12b (5/7) Bifidobacterium longum, Lactobacillus acidophilus, Enterococcus faecalis
Grąt et al. [39] 2017 55 Liver transplantation Variablea Lactobacillus lactis, Lactobacillus casei, Lactobacillus acidophilus, Bifidobacterium bifidum

GI = gastrointestinal.

aPostop only; b(/)Pre & postop (duration of preoperative treatment/postoperative treatment).
Ann Clin Nutr Metab 2022;14:10-9 https://doi.org/10.15747/ACNM.2022.14.1.10
© 2022 Ann Clin Nutr Metab