Fig. 1. Schematic diagram of stable isotope tracer-based muscle metabolic research. (A) One or more of tracers are administered into the circulation typically via intravenous infusion or oral bolus to assess muscle protein dynamics. (B, C) Samples are processed for mass spectrometry analysis of tracer enrichment of water, free amino acids (AAs) or AAs bound to proteins. (D) Finally, tracee kinetics are mathematically calculated based on the dose information of the rate of tracer administered and measured enrichment. This figure was created with BioRender.com.
D2O = Deuterium oxide.
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