Annals of Clinical Nutrition and Metabolism : eISSN 2799-8363 / pISSN 2799-7898

Table. 1.

Table. 1.

Evolution of intravenous lipid emulsions

Generation of ILE Description Potential benefits
First Soybean oil or safflower oil Information about compatibility with regularly used drugs is provided
Second Two-oil formulation including soybean oil and MCT MCTs are removed more quickly and with less peroxidation
Third Two-oil ILE using soybean oil and olive oil, resulting in a reduced amount of EFA (ω-6 FAs) Elevated doses of MUFAs produce fewer peroxides during oxidation than PUFAs
Oleic acid in olive oil is not converted to inflammatory or immune mediators
Patients who are at risk of immunosuppression or have impaired immune systems may benefit from this treatment
Fourth Four-oil ILE of soybean oil, MCT, olive oil, and fish oil Fish oil included for critically ill and surgical patient populations
Fish oil Sources of FA and energy for infants and children with IFALD and may reverse IFALD

Revised from the article of Mirtallo et al. (Nutr Clin Pract 2020;35:769-82) [7] with original copyright holder’s permission.

ILE = lipid injectable emulsion; MCT = medium-chain triglyceride; EFA = essential fatty acid; FA = fatty acid; MUFA = monounsaturated fatty acid; PUFA = polyunsaturated fatty acid; IFALD = intestinal failure-associated liver disease.

Ann Clin Nutr Metab 2023;15:2-7
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