Literature evaluation of parenteral selenium supplementation
| Study design | Patients (or participants) |
Selenium supplementation | Results | Reference |
|---|---|---|---|---|
| RCT | 38 preterm infants | 3 mcg/kg/day | Selenium supplementation prevented depletion | Daniels et al. [35] |
| Prospective | 29 ELBW infants | 2 mcg/kg/day | Twenty-six infants had serum selenium level lower than the normal 57 mcg/L | Klinger et al. [10] |
| Retrospective | 49 PN-dependent infants aged ≤1 year | Shortage period: 2.1±1.2 mcg/kg/day Nonshortage period: 3.8±1 mcg/kg/day |
A linear relationship was observed between intravenous selenium dose and selenium level. At doses ≤2 mcg/kg/day, nearly 100% of infants were deficient (P<0.01); when doses ≥6 mcg/kg/day were provided, the incidence of selenium deficiency decreased | Chen et al. [43] |
| RCT | 534 VLBW infants | 7 mcg/kg/day (PN) or 5 mcg/kg/day (oral) | Mean plasma seleniume concentration at 28 days increased in the supplemented group (0.56 mcmol/L) but decreased in the control group (0.29 mcmol/L) (P<0.0001) | Darlow et al. [34] |
RCT = randomized clinical trial; ELBW = extremely low birth weight; PN = parenteral nutrition; VLBW = very low birth weight.