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Ann Clin Nutr Metab 2023;15(3):67-71
Published online December 1, 2023
Role of nutrition in wound healing and nutritional recommendations for promotion of wound healing: a narrative review
Myoungjean Ju1, Yoonhong Kim2, Kyung Won Seo2

1Department of Nursing, Kosin University Gospel Hospital, Busan, Korea; 2Department of Surgery, Kosin University Gospel Hospital, Busan, Korea
Correspondence to: Kyung Won Seo, email:
Received June 8, 2023; Revised September 5, 2023; Accepted September 14, 2023.
© 2023 The Korean Society of Surgical Metabolism and Nutrition and The Korean Society for Parenteral and Enteral Nutrition.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Purpose: Addressing both malnutrition and wound healing requires strategic intervention. However, guidelines for adequate nutrition for a variety of wounds are lacking. Based on the latest literature review, we summarize the role of nutrition in each stage of wound healing and nutritional recommendations for wound healing.
Current concept: Wounds undergo three healing phases: inflammatory, proliferative, and remodeling. The inflammatory phase involves clotting and cleaning the wound. The proliferative phase builds the wound bed through tissue growth. In the remodeling phase, collagen strength increases. Proper nutrition is crucial throughout. During inflammation, calcium, vitamin K, A, and E, zinc, and proteins are essential. In proliferation, amino acids, B vitamins, lipids, zinc, and iron play key roles. During remodeling, vitamins C and E, zinc, and water are critical for collagen synthesis and skin cell maturation. Vulnerable groups like the elderly, newborns, and obese patients need proper nutrition for skin maintenance. For pressure ulcers with malnutrition risk, recommendations are 30–35 kcal/kg/day energy, 1.25–1.5 g/kg/day protein, and 30 mL/kg water. Supplements might be added if regular meals don’t meet needs. For diabetic foot ulcers, despite common deficiencies, the 2019 International Working Group on the Diabetic Foot advises against prioritizing nutritional interventions over standard care due to limited high-quality evidence.
Conclusion: Despite limited guidelines, nutrition assessment is vital for wound evaluation. A multidisciplinary approach is key, emphasizing nutrition’s role in wound healing. Implementing nutritional interventions tailored to the wound and the individual’s nutritional status is essential. This comprehensive strategy ensures the best wound care outcomes.
Keywords : Aged; Malnutrition; Meals; Pressure ulcer; Wound healing


Normal wound healing involves four stages: hemostasis after tissue damage, inflammation, proliferation, and remodeling. If the wound does not heal within a certain period owing to a delay in any stage of the healing process, the wound progresses to a chronic wound [1]. The pathogenesis of chronic wounds differs depending on the characteristics of the wound, but ultimately chronic wounds are caused by the deterioration or deficiency of healing factors that induce normal wound healing mechanisms. Impediments to wound healing include hypoxia, infection, cellular abnormalities, repetitive trauma due to sensory deterioration caused by neuropathies, decreased blood circulation due to pressure, and ischemia. Representative wounds include pressure injuries, diabetic foot ulcers, venous ulcers, and radiation wounds [2].

Pressure injuries are wounds in which tissue is deformed due to pressure generated at bony protrusions or when cellular damage is induced by such deformities. In particular, the sacral bone is bent and sharp; therefore, tissue deformation occurs more severely when pressure is applied in this area. In malnourished patients, the risk of developing pressure ulcers in the sacral region increases because of decreased tissue tolerance and reduced fat and muscle mass [3].

Diabetic foot ulcers are among the most common complications in patients with poorly controlled diabetes. These ulcers usually result from poor blood glucose control, underlying neuropathy, peripheral vascular disease, or poor foot care. Moreover, atherosclerosis accompanies diabetic foot ulcers in these patients; and ulcer healing is delayed due to the lack of blood contact with the wound, leading to necrosis and gangrene. Finally, chronic non-healing wounds lose nutrients through exudates and affect nutritional status because of the metabolic cost of repairing tissue damage [4].

Since chronic wounds significantly influence the metabolic pathway of nutrients, healing is delayed when nutrients are not adequately supplied even if active dressings are applied. In this scenario, simply adding an amino acid or vitamin does not promote wound healing. Moreover, although the relationship between wounds and nutrition has been established in many clinical studies, proper nutritional guidelines for various wounds are lacking. Thus, strategic interventions are required to address both malnutrition and wound healing.


Based on the latest research, we summarize the role of nutrition in each phase of wound healing. We also provide nutritional recommendations for promotion of wound healing.

Role of nutrients in each phase of wound healing

Wounds heal through inflammatory, proliferative, and remodeling phases. During the inflammatory phase, the wound is hemostatic through vasoconstriction and fibrin coagulation. The wound bed is cleaned through the activity of neutrophils and macrophages. In the proliferative phase, a wound bed is built by increasing the number of fibroblasts to form new granulation tissue. The wound bed facilitates wound closure through wound contraction and epithelialization. Finally, in the remodeling phase, collagen is remodeled to increase tensile strength. Surgical wounds may open or healed wounds may recur. Returning tissue to its pre-injury state may require as much as two years [5].

During the wound healing process, overall metabolism increases, increasing demand for calories and proteins. Malnutrition or deficiency in certain nutrients can hinder wound healing through various mechanisms. The roles of nutrients required at each stage of the healing process are shown in Fig. 1 [6].

Fig. 1. Role of nutrients in the wound healing process. Data from Korean Society of Surgical Metabolism and Nutrition (Clinical metabolism and nutrition for surgical patients; 2016) [6].


Calcium and vitamin K are required for the activation of the coagulation process and for fibrin clot formation during inflammation. These two nutrients are also involved in modifying some proteins used in clotting and bone metabolism. Moreover, vitamin A is required for macrophage, monocyte, and fibroblast migration during the early stages of inflammation; and vitamin E is essential for anti-inflammatory action and cell membrane stability. Zinc helps to regulate the immune response [7-11]. Proteins play a role in the immune system and facilitate tissue growth and repair. Specifically, arginine prepares cells for proliferation, and glutamine provides a source of glucose and is necessary for glutathione sulfonate synthesis to reduce oxidative stress [12-14].

Lipids contribute to anti-inflammatory responses, provide energy, and play a role in cell protection [15].


Amino acids are essential during the proliferation phase. Arginine helps regulate collagen deposition, strengthens neovascularization, and aids wound contraction [16,17]. Also, the vitamin B complex plays essential roles in metabolism and promotes cell proliferation. Lipids provide energy for wound healing and proliferation, act as building blocks for epidermal and dermal tissues, and are involved in the synthesis of cell membranes and the composition of the intracellular matrix [8,9]. Zinc is involved in cell proliferation and contributes to wound reconstruction. Iron forms hemoglobin, which is important for tissue perfusion throughout the healing process and aids in collagen synthesis [10,18].


Vitamin C (ascorbic acid) is necessary for collagen synthesis and stabilizes collagen’s triple-helical structure, and vitamin E reduces scarring. Furthermore, zinc is a cofactor in collagen synthesis that aids in collagen maturation. Finally, water is an important factor in wound healing but is often overlooked. Water helps with the movement and maturation of epidermal cells and provides structural elements to the cytoplasm of skin cells [13,19,20].

Nutritional assessment

Various nutrients affect wound healing depending on the wound stage; therefore, having all the necessary nutrients for wound healing at the appropriate time is important. Nutritional factors that increase the risk of developing chronic wounds include decreased body mass index (BMI), being underweight, having changes in the ability to eat independently, decreased food intake, low dietary protein intake, low serum albumin concentration, and decreased total lymphocyte count. Although a causal relationship between malnutrition and wound formation cannot be established, nutritional screening is important for identifying patients at potential risk of nutritional deficiency [21].

The National Institute for Health and Care Excellence (2012) recommends evaluating a patient’s BMI and unintentional weight loss rate and assessing the time frame for decreased nutritional intake and/or potential future nutritional intake disorders as a nutritional screening method. The Mini Nutritional Assessment and Malnutrition Universal Screening Tool is the recommended screening tool [22].

Nutritional assessment during wound healing is necessary to evaluate wound healing stages and nutritional status and to provide appropriate nutrients.

Nutrition guidelines for various wounds

Nutrition guidelines for pressure injury prevention and treatment

Certain patient groups, such as the elderly, newborns, obese patients, and critically ill patients, are vulnerable to pressure ulcer formation. Generally, appropriate nutrition is necessary for skin maintenance. However, in the case of protein-calorie malnutrition, the skin’s elasticity decreases, often leading to pressure injury. Evidence-based management plans centered on individualized nutritional interventions can prevent skin damage [23].

The 2019 International Clinical Practice Guidelines propose the following nutritional interventions for pressure ulcer risk and pressure ulcer groups (Table 1) [23].

Suggestion of supplementation regimen for malnourished or at risk of malnutrition

Nutrient Stage I pressure injury Stage 2 or greater pressure injury
Calories 30–35 kcal/kg/day Over than 30–35 kcal/kg/day
Protein 1.2–1.5 g/kg/day Over than 1.2–1.5 g/kg/day
Additional oral
- Arginine, zinc, antioxidant supplements

Data from European Pressure Ulcer Advisory Panel, 2019 [23].

Pressure ulcer risk group with malnutrition risk

∙ Energy: 30–35 kcal/kg/day

∙ Protein: 1.25–1.5 g/kg/day

∙ Water: 30 mL/kg or 1 mL/kcal

∙ If nutritional requirements cannot be met through meals, offer high-calorie, high-protein fortified foods and/or nutritional supplements in addition to the usual diet for adults.

Patients with stage 2 or higher pressure injuries and malnutrition risk or malnutrition

∙ Energy: 30–35 kcal/kg/day

∙ Protein: 1.25–1.5 g/kg/day

∙ Water: 30 mL/kg or 1 mL/kcal

∙ If nutritional requirements cannot be met through meals, offer high-calorie, high-protein nutritional supplements in addition to the usual diet for adults.

∙ Provide high-calorie, high-protein, arginine, zinc, and antioxidant oral nutritional supplements or enteral formulas for adults.

Nutrition guidelines for diabetic foot ulcer patients

Nutritional deficiencies are common in patients with chronic diabetic foot ulcers, and specific micronutrient deficiencies are common and associated with impaired wound healing and increased amputation risk in diabetic foot ulcer patients [14-16]. Recent studies have found that patients newly diagnosed with diabetes are commonly malnourished, which is associated with impaired wound healing. However, the number of high-quality randomized controlled trials is small, and the evidence on the effects of nutritional interventions in patients with diabetic foot ulcers is uncertain. The IWGDF (International Working Group on the Diabetic Foot) 2019 guidelines [24] are as follows:

Do not use interventions aimed at correcting the nutritional status (including supplementation of protein, vitamins, trace elements, and pharmacotherapy with agents promoting angiogenesis) of patients with diabetic foot ulcers to improve healing, in preference to the best standard of care (GRADE recommendation: Strong; Quality of evidence: Low) [25].


Although nutritional guidelines for each type of wound have been presented along with the importance of nutrition in healing delayed chronic wounds, nutritional evaluation is often overlooked in clinical practice because the focus is on local wound treatments. Furthermore, although detailed guidelines are lacking, nutritional assessment is essential for evaluating wounds. To this end, a multidisciplinary approach is needed to include nutritional assessment in wound evaluation items and to actively perform nutritional interventions according to wound and nutritional status.

Authors’ contribution

Conceptualization: KWS. Formal analysis: MJ, KWS. Investigation: MJ, YK, KWS. Methodology: MJ, KWS. Project administration: MJ, KWS. Writing – original draft: MJ, KWS. Writing – review & editing: MJ, YK, KWS.

Conflict of interest

Kyung Won Seo is an editorial board member of the journal, but was not involved in the review process of this manuscript. Otherwise, there is no conflict of interest to disclose.



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Supplementary materials


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