Annals of Clinical Nutrition and Metabolism

Original Articles

Effects of enteral nutrition formulas with varying carbohydrate amounts on glycemic control in diabetic mice: Yukari Miki, Kazuo Hino; Ann Clin Nutr Metab 2025;17(1):85-93. Published online April 1, 2025; DOI: https://doi.org/10.15747/ACNM.25.0006

Abstract PDF ePub: Purpose
This study evaluated the effects of an 8‑week liquid diets with different carbohydrate contents–64% energy in HINE E‑Gel (ST) and 50% energy in HINE E‑Gel LC (LC)–on glycemic control and nutritional status in a mouse model of type 2 diabetes mellitus (db/db mice). The objective was to determine whether reducing carbohydrate intake within the Dietary Reference Intakes for Japanese people improves glycemic control indices, addressing the evidence gap in regarding the long‑term safety and efficacy of low‑carbohydrate enteral nutrition in patients with diabetes.
Methods
db/db mice (n=10 per group) and non‑diabetic db/m mice (n=4) as controls were fed ST, LC, or AIN‑93G diets ad libitum for 8 weeks. The diets primarily differed in carbohydrate content (64% in ST vs. 50% in LC). Blood glucose and glycated hemoglobin (HbA1c), plasma glucose and glycoalbumin, organ weights, and renal function markers were measured weekly or at 4 and 8 weeks. Histopathological examinations of the liver and kidneys were performed at 8 weeks.
Results
At 8 weeks, the LC group showed significantly lower plasma glucose (P=0.0051) and glycoalbumin (P=0.0013) levels compared to the ST group, with a trend toward lower HbA1c (P=0.0514). Although body weight was significantly higher in the LC group (P=0.0038), there were no significant differences between the ST and LC groups in caloric intake, renal function, or histopathological findings.
Conclusion
Reducing carbohydrate intake to 50% of total energy within dietary guidelines may improve glycemic control in diabetic mice, suggesting the need for further long‑term evaluation for clinical applications.

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Risk Factor of Anemia after a Gastrectomy in Patients with Gastric Cancer: In Jun Yang, Dong-Wook Kim, Ye Seob Jee; Surg Metab Nutr 2019;10(1):15-19. Published online June 30, 2019; DOI: https://doi.org/10.18858/smn.2019.10.1.15

Abstract PDF ePub

Purpose:

In this study, we evaluate hematologic change of iron and vitamin B₁₂ on post-operative anemia after gastrectomy for gastric cancer.

Materials and Methods:

The patients with gastric cancer who underwent gastrectomy between January 2013 and December 2013 in Dankook university hospital were retrospectively reviewed. The 62 patients were followed up for 36 month postoperatively.

Results:

The incidences of anemia in female patients were turned out to be higher than those in male patients but there were no statistical difference; (44.4% vs 40.9%, P=0.399) at 6 month, (33.3% vs 25.0%, P=0.252) at 12 month, (22.2% vs 15.9%, P=0.277) at 18 month, (27.8% vs 15.9%, P=0.142) at 36 month after surgery. Patients with distal gastrectomy after the surgery showed decreasing incidence of anemia while patients with total gastrectomy showed decreasing incidence of anemia until 12 months but increasing incidence after that time.

Conclusion:

Anemia, Vitamin B₁₂ and iron deficiency must be evaluated after surgery for gastric cancer and active treatment is necessary as needed.

Citations

Citations to this article as recorded by

Post-gastrectomy anemia and ferritin dynamics: key determinants of prognosis and clinical management in patients with gastric cancer
Eun Young Kim, Kyo Young Song, Dong Jin Kim
Frontiers in Oncology.2025;[Epub] CrossRef

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