Annals of Clinical Nutrition and Metabolism

Original Article

Preprocedural prognostic nutritional index predicts early gastrointestinal symptoms after percutaneous endoscopic gastrostomy or percutaneous radiologic gastrostomy in Korea: a retrospective cohort study: Yoonhong Kim, Jee Young Lee, Yeajin Moon, Seung Hun Lee, Kyung Won Seo, Ki Hyun Kim; Ann Clin Nutr Metab 2025;17(3):196-202. Published online December 1, 2025; DOI: https://doi.org/10.15747/ACNM.25.0032

Graphical Abstract Abstract PDF: Purpose
The prognostic nutritional index (PNI) reflects immunonutritional status and is a well-established predictor of surgical outcomes. Although its association with post-gastrostomy mortality has been documented, its relationship with early gastrointestinal (GI) symptoms remains unclear. This study aimed to evaluate whether the preprocedural PNI predicts early GI symptoms following percutaneous gastrostomy, including percutaneous endoscopic gastrostomy (PEG) and percutaneous radiologic gastrostomy (PRG).
Methods
This retrospective study included 71 adults who underwent PEG or PRG. Early GI symptoms, such as nausea, vomiting, and diarrhea, occurring within 7 days were recorded. The preprocedural PNI, neutrophil-to-lymphocyte ratio (NLR), and the C-reactive protein (CRP)-to-albumin ratio were analyzed using logistic regression to identify predictors. Receiver operating characteristic (ROC) analysis was performed to assess the PNI’s discriminative performance.
Results
Early GI symptoms occurred in 21 of 71 patients (29.6%). In univariate analysis, the PNI (P=0.009) and CRP-to-albumin ratio (P=0.018) were significant predictors, whereas NLR was not (P=0.125). After adjustment for potential confounders, including age, sex, body mass index, and NLR, the PNI remained an independent predictor of early GI symptoms (adjusted odds ratio, 0.90; 95% confidence interval, 0.83–0.98; P=0.021). ROC analysis for the PNI produced an area under the curve of 0.696, with an optimal cutoff value of 41.3 (sensitivity 70.6%, specificity 66.7%).
Conclusion
A lower preprocedural PNI is independently associated with the development of early GI symptoms after gastrostomy. The PNI may serve as a practical screening tool to identify high-risk patients who could benefit from preemptive nutritional optimization.

182 View
9 Download

Reviews

Role of nutrition in wound healing and nutritional recommendations for promotion of wound healing: a narrative review: Myoungjean Ju, Yoonhong Kim, Kyung Won Seo; Ann Clin Nutr Metab 2023;15(3):67-71. Published online December 1, 2023; DOI: https://doi.org/10.15747/ACNM.2023.15.3.67

Abstract PDF

Purpose: Addressing both malnutrition and wound healing requires strategic intervention. However, guidelines for adequate nutrition for a variety of wounds are lacking. Based on the latest literature review, we summarize the role of nutrition in each stage of wound healing and nutritional recommendations for wound healing.
Current concept: Wounds undergo three healing phases: inflammatory, proliferative, and remodeling. The inflammatory phase involves clotting and cleaning the wound. The proliferative phase builds the wound bed through tissue growth. In the remodeling phase, collagen strength increases. Proper nutrition is crucial throughout. During inflammation, calcium, vitamin K, A, and E, zinc, and proteins are essential. In proliferation, amino acids, B vitamins, lipids, zinc, and iron play key roles. During remodeling, vitamins C and E, zinc, and water are critical for collagen synthesis and skin cell maturation. Vulnerable groups like the elderly, newborns, and obese patients need proper nutrition for skin maintenance. For pressure ulcers with malnutrition risk, recommendations are 30–35 kcal/kg/day energy, 1.25–1.5 g/kg/day protein, and 30 mL/kg water. Supplements might be added if regular meals don’t meet needs. For diabetic foot ulcers, despite common deficiencies, the 2019 International Working Group on the Diabetic Foot advises against prioritizing nutritional interventions over standard care due to limited high-quality evidence.
Conclusion: Despite limited guidelines, nutrition assessment is vital for wound evaluation. A multidisciplinary approach is key, emphasizing nutrition’s role in wound healing. Implementing nutritional interventions tailored to the wound and the individual’s nutritional status is essential. This comprehensive strategy ensures the best wound care outcomes.

Citations

Citations to this article as recorded by

Electrospun-based nanofibers as ROS-scavenging scaffolds for accelerated wound healing: a narrative review
Mohammad Ebrahim Astaneh, Narges Fereydouni
International Journal of Polymeric Materials and Polymeric Biomaterials.2025; 74(15): 1349. CrossRef
Implementing a screening protocol for food insecure patients within a long‐term acute care hospital (LTACH): A community health needs assessment (CHNA)
Molly MacDonald, Christopher Stimson, Marti Samsel, Tina Gross
Nutrition in Clinical Practice.2025; 40(6): 1598. CrossRef
Nanoformulations Loaded with Phytochemicals for Combating Wound Infections and Promoting Wound Healing: Current Applications and Innovations
Panoraia I. Siafaka, Androulla N. Miliotou, Mehmet Evren Okur, Gökçe Karaotmarlı Güven, Ioannis D. Karantas, Neslihan Üstündağ Okur
Applied Sciences.2025; 15(10): 5413. CrossRef
Combining Topical Oxygen and Negative-Pressure Wound Therapy: New Insights from a Pilot Study on Chronic Wound Treatment
Bartosz Molasy, Mateusz Frydrych, Rafał Kuchciński, Stanisław Głuszek
Journal of Clinical Medicine.2025; 14(15): 5564. CrossRef
Undifferentiated connective tissue dysplasia and skin: what to do? Dietitian’s position
E. A. Nikitina, S. V. Orlova, T. T. Batysheva, N. V. Balashova, M. V. Alekseeva
Medical alphabet.2025; 1(19): 60. CrossRef
Nutritional Immunity in Wound Infection: Unveiling the Role of Dietary Elements in Host–Pathogen Interaction
Chaoming Chen, Xuanfan Hu, Da He, Xuemei He, Lan Shen
Food Science & Nutrition.2025;[Epub] CrossRef
Role of Nutrients and Diet in Wound Healing: The Emerging Paradigm for Effective Therapy
Aishik Banerjee, Arup Ghosh, Subhrajyoty Basu, Soumitra Sahana, Amit Kundu, Sumanta Mondal
Current Indian Science.2025;[Epub] CrossRef
Assessment of energy requirements in patients with obesity: A narrative review
Cagney Cristancho, Kris M. Mogensen, Malcolm K. Robinson
Nutrition in Clinical Practice.2025;[Epub] CrossRef
Lueyang Black‐Boned Chicken and Black Bean Soup Promoting the Acute Healing of Skin Wounds, Accompanying Special Flavor Substances
Mengya Zhao, Zining Luo, Pengyan Tong, Yining Jia, Xin Yang, Jing Liu, Fangyu Long
Food Chemistry International.2025;[Epub] CrossRef
Cancer-Related Malnutrition and Oxidative Stress in Colorectal Cancer Surgery: A Narrative Review of Pathophysiology and Postoperative Outcomes
Andrii Zahorodnii, Alicja Jelska, Paulina Głuszyńska, Hady Razak Hady
Antioxidants.2025; 14(11): 1289. CrossRef
UCI Sports Nutrition Project: The Role of Nutrition in the Prevention and Management of Illnesses and Injuries in Elite Cycling
Patrick B. Wilson, David B. Pyne, Adrian Rotunno
International Journal of Sport Nutrition and Exercise Metabolism.2025; : 1. CrossRef
Clinical Impact of Nutritional Intervention on Pressure Injury Healing in a Paraplegic Patient: A Case Report
Young ran Kim, Mi young Jang, Jun ho Park
Clinical Nutrition Research.2025; 14(4): 241. CrossRef
Impact of Epigenetics, Diet, and Nutrition-Related Pathologies on Wound Healing
John Hajj, Brandon Sizemore, Kanhaiya Singh
International Journal of Molecular Sciences.2024; 25(19): 10474. CrossRef

58,079 View
1,526 Download
13 Crossref

Efficacy of monounsaturated fatty acids in reducing risk of the cardiovascular diseases, cancer, inflammation, and insulin resistance: a narrative review: Ki Hyun Kim, Yoonhong Kim, Kyung Won Seo; Ann Clin Nutr Metab 2023;15(1):2-7. Published online April 1, 2023; DOI: https://doi.org/10.15747/ACNM.2023.15.1.2

Abstract PDF

Purpose: The purpose of this review is to explore the potential benefits of monounsaturated fatty acids (MUFAs), specifically those found in olive oil, on weight loss, cardiovascular disease, cancer, inflammation, and insulin resistance. Additionally, this review examines the use of olive oil–based intravenous lipid emulsions (ILEs) in providing parenteral nutrition to patients with diverse needs.
Current concept: MUFAs, found in olive oil, nuts, and some animal foods, have been found to have numerous health benefits. A diet high in MUFAs can aid in weight loss and reduce the risk of cardiovascular disease. Olive oil, in particular, has been linked to a lower risk of cancer, inflammation, and insulin resistance. In addition, olive oil–based ILEs have been utilized for over two decades and are well tolerated by patients requiring parenteral nutrition.
Conclusion: A diet rich in MUFAs, specifically from olive oil, can provide numerous health benefits, including weight loss and reducing the risk of cardiovascular disease, cancer, inflammation, and insulin resistance. Additionally, olive oil–based ILEs have been shown to effectively provide nutrients to diverse populations requiring parenteral nutrition and have demonstrated the ability to preserve immune function and induce less lipid peroxidation than other ILEs. Further research is needed to fully understand the potential benefits of MUFAs and olive oil-based ILEs, but current evidence suggests that they may be a valuable addition to a healthy diet and medical treatment.

Citations

Citations to this article as recorded by

The impact of Lactiplantibacillus plantarum on the cream composition: Insight into changes of vitamin D3 content and fatty acid composition
Tetiana Dyrda-Terniuk, Viorica Railean, Aleksandra Bogumiła Florkiewicz, Justyna Walczak-Skierska, Mateusz Kolankowski, Joanna Rudnicka, Dorota Białczak, Paweł Pomastowski
International Dairy Journal.2025; 161: 106118. CrossRef
Palmitoleic and oleic fatty acids as biomarkers for coronary heart disease: A predictive model
Guangzhou Wang, Lin Zhou, Zhengfang Wang, Asmaa Ali, Liang Wu
Irish Journal of Medical Science (1971 -).2025; 194(1): 59. CrossRef
Effects of daily extra virgin olive oil consumption on biomarkers of inflammation and oxidative stress: a systematic review and meta-analysis
Jéssica Vidal Damasceno, Anderson Garcez, Andressa Anelo Alves, Isabella Rosa da Mata, Simone Morelo Dal Bosco, Juliano Garavaglia
Critical Reviews in Food Science and Nutrition.2025; : 1. CrossRef
Macrophages: their role in immunity and their relationship with fatty acids in health and disease
Mayte Rueda-Munguía, Luis Alberto Luévano-Martínez, Gerardo García-Rivas, Elena Cristina Castillo, Omar Lozano
Frontiers in Immunology.2025;[Epub] CrossRef
Evaluation of the Nutritional Value of Prunus dulcis Blossoms and the Antioxidant Compounds of Their Extracted Oil Using Green Extraction Method
Theodoros Chatzimitakos, Vassilis Athanasiadis, Konstantina Kotsou, Ioannis Makrygiannis, Eleni Bozinou, Stavros I. Lalas
Applied Sciences.2024; 14(5): 2001. CrossRef
Oleic Acid and Succinic Acid: A Potent Nutritional Supplement in Improving Hepatic Glycaemic Control in Type 2 Diabetic Sprague–Dawley Rats
Kemmoy G. Lattibeaudiere, Ruby Lisa Alexander-Lindo, Mozaniel Oliveira
Advances in Pharmacological and Pharmaceutical Sciences.2024;[Epub] CrossRef

30,940 View
83 Download
6 Crossref

First
Prev
Page of 1
Next
Last

Search